Unnatural Selection was a Tier 2 Relic in the Twisted League. It could be chosen once the player has chosen a Tier 1 Relic and has earned 400 points. Unnatural Selection gave the following benefit:
Players can now choose which farming contract and slayer assignment they would like.
Players were unable to choose a farming contract that they have just completed, so despite the above wording they must cycle between at least two different contracts.
Cancelling a Medium or Hard farming contract did not give a choice about which lower-level contract replaces it.
Trivia
It is a pun on the term Natural Selection which stems from Charles Darwin's well established Theory of Evolution.
Could also be a reference to the song by Muse titled "Unnatural Selection".