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As a strike spell, Fire Strike is one of the only spells that can be used to damage Salarin the twisted. When used this way, its damage is scaled up to match that of Fire Bolt.
Trivia
Prior to an update on May 29, 2024, Fire Strike had the highest base maximum hit out of all the strike spells. For this reason, it was commonly used by low-level players to defeat enemies and quest bosses with a much higher combat level, such as the Khazard warlord in the Tree Gnome Village quest. After the update, all of the strike spells have a base maximum hit equal to the strongest strike spell that the player has unlocked, making Wind Strike a cheaper but equally effective alternative (unless the player is fighting a monster that is specifically weak to fire spells).